Basic Information
| LncRNA/CircRNA Name | HCP5 |
| Synonyms | human leukocyte antigen (HLA) Complex P5 |
| Region | GRCh38_6:31400702-31477506 |
| Ensemble | ENSG00000206337 |
| Refseq | NR_040662 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | RT-qPCR, Western blot analysis, Dual Luciferase Reporter Assay |
| Sample | OSCC tissues,OSCC cell lines, including SCC-4, Tca8113 and SCC-9, and human normal oral keratinocyte NOK cell line |
| Expression Pattern | up-regulated |
| Function Description | HCP5 expression was significantly increased in OSCC tissues and cell lines. High HCP5 level was associated with the aggressive clinicopathological characteristics and poor prognosis of OSCC patients. In vitro gain- and loss-of-function experiments showed that HCP5 overexpression promoted, whereas HCP5 knockdown inhibited the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of OSCC cells. Mechanistically, we confirmed that HCP5 might serve as a competitive endogenous RNA (ceRNA) for miR-140-5p. |
| Pubmed ID | 31849534 |
| Year | 2019 |
| Title | Long Non-Coding RNA HCP5 Facilitates Cell Invasion And Epithelial-Mesenchymal Transition In Oral Squamous Cell Carcinoma By miR-140-5p/SOX4 Axis |
External Links
| Links for HCP5 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |