Basic Information
| LncRNA/CircRNA Name | AB073614 |
| Synonyms | NA |
| Region | GRCh38_3:149173591-149175492 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | glioma tissues, cell line (U251) |
| Expression Pattern | up-regulated |
| Function Description | AB073614 expression was found to be significantly upregulated in glioma tissues compared with adjacent normal tissues, with a higher level in high-grade glioma. AB073614 expression was significantly upregulated in both glioma tissues and cell lines, and glioma patients with high AB073614 expression had lower overall survival rates. AB073614 promoted the progression of glioma by targeting SOX7 to activate the Wnt/B-catenin signaling pathway, suggesting that the inhibition of AB073614 might be a potential target for therapeutic intervention in glioma patients. AB073614 induced Wnt/B-catenin signaling activity by repressing SOX7 expression. |
| Pubmed ID | 29029454 |
| Year | 2017 |
| Title | Long noncoding RNA AB073614 promotes the malignance of glioma by activating Wnt/B-catenin signaling through downregulating SOX7. |
External Links
| Links for AB073614 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |