Basic Information
| LncRNA/CircRNA Name | HEIRCC |
| Synonyms | LINC00887, HEIRCC |
| Region | GRCh38_3:194296465-194312803 |
| Ensemble | ENSG00000214145 |
| Refseq | NR_024480 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | Microarray, qPCR, RNAi, Western blot, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | ccRCC tissues, cell lines (786-O, A498, ACHN) |
| Expression Pattern | up-regulated |
| Function Description | HEIRCC was up-regulated in RCC tissues and cell lines. The high expression of HEIRCC is associated closely with the clinical pathology features such as larger tumor size, poor differentiation, lymphatic metastasis. In vitro assays revealed that HEIRCC knockdown could inhibit cell proliferation, trigger late apoptosis, suppress cell migration and invasion. We further demonstrated that depletion of HEIRCC reduce the epithelial to mesenchymal transition (EMT) program by regulating expression levels of EMT-associated markers in RCC cells. |
| Pubmed ID | 28030807 |
| Year | 2017 |
| Title | High expression of the long non-coding RNA HEIRCC promotes Renal Cell Carcinoma metastasis by inducing epithelial-mesenchymal transition. |
External Links
| Links for HEIRCC | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |