Basic Information
| LncRNA/CircRNA Name | HHIP-AS1 |
| Synonyms | NA |
| Region | GRCh38_4:144642922-144661357 |
| Ensemble | ENSG00000248890 |
| Refseq | NR_037595 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Western blot , RIP , in vitro knockdown etc. |
| Sample | HCC tissues and adjacent normal liver tissues ,cell lines (Hep3B, PLC/PRF/5, Huh7, HepG2 and MHCC-97 h ) |
| Expression Pattern | down-regulated |
| Function Description | The expression levels of HHIP-AS1 were significantly decreased in HCC tissues. Downregulation of HHIP-AS1 expression correlated with larger tumor size, metastasis, and advanced TNM stage, and also predicted worse overall survival rate of HCC patients.The biological function of HHIP-AS1 was identified to suppress HCC cell proliferation, migration and invasion, while promote apoptosis.HHIP-AS1 interacted with and positively regulated the stability of HHIP mRNA in a HuR-dependent manner. HHIP-AS1 exerted its suppressive effects through HHIP. |
| Pubmed ID | 31604528 |
| Year | 2019 |
| Title | A Novel Long Noncoding RNA HHIP-AS1 Suppresses Hepatocellular Carcinoma Progression Through Stabilizing HHIP mRNA |
External Links
| Links for HHIP-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |