Basic Information
| LncRNA/CircRNA Name | HIF1A-AS1 |
| Synonyms | HIF1A-AS1, 5'aHIF-1A, 5'aHIF1alpha |
| Region | GRCh38_14:61681041-61695823 |
| Ensemble | ENSG00000258777 |
| Refseq | NR_047116 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR |
| Sample | colon cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | differentiation degree, tumor size, TNM stage, T stage, N stage, M stage and serum level of HIF1A-AS1 were all linked to CRC prognosis.Compared to CRC patients with low HIF1A-AS1 expression, high expression of patients were associated with a shorter 5-year-survival rate. lower differentiation degree, tumor > 5cm and higher expression of HIF1A-AS1 were independent risk factors affecting the survival rate of patients with CRC. |
| Pubmed ID | 28946548 |
| Year | 2017 |
| Title | Elevated serum level of lncRNA-HIF1A-AS1 as a novel diagnostic predictor for worse prognosis in colorectal carcinoma. |
External Links
| Links for HIF1A-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |