Basic Information
| LncRNA/CircRNA Name | HIF1A-AS2 |
| Synonyms | NA |
| Region | GRCh38_14:61715558-61751097 |
| Ensemble | ENSG00000258667 |
| Refseq | NR_045406 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | RT-PCR, Western blotting, Luciferase reporter assay |
| Sample | osteosarcoma samples,osteosarcoma cell lines (U2OS, SoSP-M, SaOS-2, MG-63) and an osteoblast cell line (hFOB 1.19) |
| Expression Pattern | up-regulated |
| Function Description | the expression of HIF1A-AS2 was upregulated in the osteosarcoma samples compared with the expression in noncancerous samples.patients with high HIF1A-AS2 expression had a shorter overall survival. Ectopic expression of HIF1A-AS2 enhanced osteosarcoma cell proliferation, cell cycle progression and invasion. We found that overexpression of miR-129-5p decreased the luciferase activity of wild-type (WT) HIF1A-AS2 but not mutant HIF1A-AS2. Ectopic expression of HIF1A-AS2 suppressed miR-129-5p expression in MG-63 cells. |
| Pubmed ID | 31866584 |
| Year | 2019 |
| Title | LncRNA HIF1A-AS2 Promotes Osteosarcoma Progression by Acting as a Sponge of miR-129-5p |
External Links
| Links for HIF1A-AS2 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |