Basic Information
| LncRNA/CircRNA Name | HIF1A-AS2 |
| Synonyms | HIF1A-AS2, 3'aHIF-1A, aHIF |
| Region | GRCh38_14:61715558-61751097 |
| Ensemble | ENSG00000258667 |
| Refseq | NR_045406 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR, Western blot, Luciferase reporter assay, RIP |
| Sample | human CRC tissues, Human CRC cell lines (SW620, DLD-1, HT-29, HCT116) |
| Expression Pattern | up-regulated |
| Function Description | immunofluorescence, all those assays reflected a fact that as a ceRNA, HIF1A-AS2 could directly bind with miR-129-5p, and could positively affect cell proliferation, invasion and EMT formation by regulation of the expression of miR-129-5p and DNMT3A. |
| Pubmed ID | 29278853 |
| Year | 2017 |
| Title | LncRNA HIF1A-AS2 positively affects the progression and EMT formation of colorectal cancer through regulating miR-129-5p and DNMT3A. |
External Links
| Links for HIF1A-AS2 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |