Basic Information
| LncRNA/CircRNA Name | HMMR-AS1 |
| Synonyms | NA |
| Region | GRCh38_5:163483065-163494058 |
| Ensemble | ENSG00000251018 |
| Refseq | NR_109892 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, Luciferase reporter assay etc. |
| Sample | breast cancer tissues, cell lines (MDA-MB-231 and MDA-MB-468) |
| Expression Pattern | up-regulated |
| Function Description | We found that the expression of HMMR was positively correlated with HMMR-AS1 (RP11-80G.1). When HMMR-AS1 (RP11-80G.1) was knocked down, the expression of HMMR markedly reduced. Furthermore, in MDA-MB-231 and MDA-MB-468 breast cancer cells, the proliferation and migration abilities were remarkably suppressed via knocking down HMMR-AS1 (RP11-80G.1) in vitro. |
| Pubmed ID | 27920576 |
| Year | 2016 |
| Title | The HMMR-AS1 expression was markedly higher in BLBCs in contrast to those in non-BLBC subtypes. HMMR antisense RNA 1, a novel long noncoding RNA, regulates the progression of basal-like breast cancer cells. |
External Links
| Links for HMMR-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |