Basic Information
| LncRNA/CircRNA Name | HNF1A-AS1 |
| Synonyms | NA |
| Region | GRCh38_12:120941728-120980965 |
| Ensemble | ENSG00000241388 |
| Refseq | NR_024345 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, RIP, Luciferase reporter assay etc |
| Sample | GC tissue and six samples of nontumourous gastric mucosa tissue,cell lines (MKN-45 and BGC-823) |
| Expression Pattern | up-regulated |
| Function Description | High expression of HNF1A-AS1 is correlated with lymph node metastasis in GC patients.HNF1A-AS1 worked as a ceRNA and promoted PI3K/AKT signalling pathway-mediated GC metastasis by sponging miR-30b-3p, offering novel insights of the metastasis mechanism in GC. |
| Pubmed ID | 32336754 |
| Year | 2020 |
| Title | LncRNA-HNF1A-AS1 functions as a competing endogenous RNA to activate PI3K/AKT signalling pathway by sponging miR-30b-3p in gastric cancer. |
External Links
| Links for HNF1A-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |