Basic Information
| LncRNA/CircRNA Name | HNF1A-AS1 |
| Synonyms | HNF1A-AS1, C12orf27, NCRNA00262 |
| Region | GRCh38_12:120941728-120980965 |
| Ensemble | ENSG00000241388 |
| Refseq | NR_024345 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal adenocarcinoma |
| ICD-0-3 | C15 |
| Methods | RNA-seq, Microarray, qPCR, RNAi, Western blot etc. |
| Sample | esophageal adenocarcinoma tissues, cell lines (HEEpiC, SKGT-4, OE33 etc.) |
| Expression Pattern | up-regulated |
| Function Description | We discovered that a lncRNA, HNF1A-AS1, is markedly upregulated in human primary EACs relative to their corresponding normal oesophageal tissues. We further discovered that HNF1A-AS1 knockdown significantly inhibited cell proliferation and anchorage-independent growth, suppressed S-phase entry, and inhibited cell migration and invasion in multiple in vitro EAC models. Our findings suggest that dysregulation of HNF1A-AS1 participates in oesophageal tumorigenesis, and that this participation may be mediated, at least in part, by modulation of chromatin and nucleosome assembly as well as by H19 induction. |
| Pubmed ID | 24000294 |
| Year | 2014 |
| Title | Long non-coding RNA HNF1A-AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells. |
External Links
| Links for HNF1A-AS1 | GenBank HGNC NONCODE |
| Links for esophageal adenocarcinoma | OMIM COSMIC |