Basic Information
| LncRNA/CircRNA Name | HNF1A-AS1 |
| Synonyms | HNF1A-AS1, C12orf27, NCRNA00262 |
| Region | GRCh38_12:120941728-120980965 |
| Ensemble | ENSG00000241388 |
| Refseq | NR_024345 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | ESCC tissues, cell lines (KYSE70, KYSE450, EC109 and EC970) |
| Expression Pattern | up-regulated |
| Function Description | upregulated expression of HAS1 was detected in ESCC tissues and four human ESCC cell lines (KYSE70, KYSE450, EC109 and EC970) compared with normal tissues and cell lines.HAS1-siRNA counteracted the effect of miR-214 inhibitor on cell viability and mobility in EC109 cells. HAS1-siRNA abated the role of miR-214 inhibitor in promoting tumor growth and metastasis. HAS1-miR-214-SOX-4 pathway in regulating the growth and metastasis of ESCC, providing a promising target for ESCC therapy. |
| Pubmed ID | 28656277 |
| Year | 2017 |
| Title | HNF1A-AS1 promotes growth and metastasis of esophageal squamous cell carcinoma by sponging miR-214 to upregulate the expression of SOX-4. |
External Links
| Links for HNF1A-AS1 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |