Basic Information
| LncRNA/CircRNA Name | HNF1A-AS1 |
| Synonyms | HNF1A-AS1, C12orf27, NCRNA00262 |
| Region | GRCh38_12:120941728-120980965 |
| Ensemble | ENSG00000241388 |
| Refseq | NR_024345 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy/apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, in vitro knockdown, RNAi etc. |
| Sample | cell lines (T24, J82, UMUC3, 5637, SV-HUC-1), BC tissues |
| Expression Pattern | up-regulated |
| Function Description | HNF1A-AS1 is upregulated in clinical BC tissues and cultured BC cells.HNF1A-AS1 promotes cell viability and colony formation in the BC cell lines. Knockdown of HNF1A-AS1 arrested BC cell cycle progression by notably accumulating cells in G 0 /G 1 phase in T24 and 5637 cells. |
| Pubmed ID | 29541223 |
| Year | 2018 |
| Title | Long non-coding RNA HNF1A-AS1 promotes cell viability and migration in human bladder cancer. |
External Links
| Links for HNF1A-AS1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |