Basic Information
| LncRNA/CircRNA Name | HNRNPKP2 |
| Synonyms | |
| Region | GRCh38_2:136199114-136200503 |
| Ensemble | ENSG00000227347 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot etc. |
| Sample | serum, gastric cancer cell lines (BGC823, SGC7901, MGC803 and HGC27), colon cancer cell lines (SW620, LoVo and HCT116), breast cancer cell lines (MCF-7, MDA-MB-231, MDA-MB-435), liver cancer cell lines (PLC/PRF/5 and HepG2) |
| Expression Pattern | differential expression |
| Function Description | In mechanism, HNRNPKP2 as a lncRNA was upregulated after DC-SIGNR knockdown. Importantly, STAT5A promoted HNRNPKP2 expression after knockdown DC-SIGNR. Furthermore after HNRNPKP2 depletion, the downstream target gene CXCR4 was downregulated. |
| Pubmed ID | 28403883 |
| Year | 2017 |
| Title | DC-SIGNR by influencing the lncRNA HNRNPKP2 upregulates the expression of CXCR4 in gastric cancer liver metastasis |
External Links
| Links for HNRNPKP2 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |