Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | NA |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RT-qPCR, Western blot |
| Sample | CRC tissues,cell lines (HT29, SW20, HCT116, and SW480),bloo |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR functioned as a molecular sponge of miR-93 to regulate ATG12 expression. HOTAIR knockdown potentiated radiosensitivity through regulating miR-93/ATG12 axis in CRC |
| Pubmed ID | 32144238 |
| Year | 2020 |
| Title | Long non-coding RNA HOTAIR knockdown enhances radiosensitivity through regulating microRNA-93/ATG12 axis in colorectal cancer |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |