Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | NA |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | celastrol | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | small cell lung cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR, Western blotting analysis, Luciferase reporter assays |
| Sample | SCLC cell lines H69, H69AR and H446,H446AR |
| Expression Pattern | up-regulated |
| Function Description | HOXA1 methylation induced by HOTAIR contributes to the chemoresistance of SCLC by regulating the NF-?B pathway. NF-?B inhibitors may be used in chemotherapy resistant patients with increased HOTAIR expression. |
| Pubmed ID | 31934137 |
| Year | 2019 |
| Title | HOTAIR Contributes to Chemoresistance by Activating NF-?B Signaling in Small-Cell Lung Cancer |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for small cell lung cancer | OMIM COSMIC |