Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOX transcript antisense RNA |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blot Assay, Dual Luciferase Reporter Assay, RIP |
| Sample | GC tissue samples,gastric carcinoma cell lines MGC-803 (CQ80145) and AGS (H007) and human stomach normal epithelial cell lines GES-1 (H054) |
| Expression Pattern | up-regulated |
| Function Description | The levels of HOTAIR and KLF12 were significantly upregulated and the level of miR-618 was strikingly downregulated in GC tissues and cells. miR-618 was verified as a direct target of HOTAIR or KLF12. |
| Pubmed ID | 31819516 |
| Year | 2019 |
| Title | Long Non-Coding RNA HOTAIR Modulates KLF12 to Regulate Gastric Cancer Progression via PI3K/ATK Signaling Pathway by Sponging miR-618 |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |