Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | NA |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR, Western blot analysis, Dual luciferase reporter gene assay, RIP |
| Sample | CRC and adjacent tissues,CRC cell lines SW620, SW480, HCT-8, HCT-8/5-FU and LoVo |
| Expression Pattern | up-regulated |
| Function Description | Upregulated HOTAIR and ST6GAL1 are crucial predictors for poor CRC prognosis.The regulatory role of HOTAIR/miR-214/ST6GAL1 axis also impacts CRC procession.The HOTAIR/miR-214/ST6GAL1 axis commands the CRC malignancy by modifying c-Met with sialylation and activating JAK2/STAT3 pathway. |
| Pubmed ID | 31694696 |
| Year | 2019 |
| Title | The HOTAIR/miR-214/ST6GAL1 Crosstalk Modulates Colorectal Cancer Procession Through Mediating Sialylated c-Met via JAK2/STAT3 Cascade |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |