Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | NA |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qRT-PCR , Luciferase reporter assay , in vitro knockdown etc. |
| Sample | thyroid cancer tissues and corresponding adjacent normal thyroid tissues ,human thyroid follicular cell line Nthy-ori3-1 , human thyroid cancer cell lines (TPC-1, FTC-133,B-CPAP and SW579) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR was significantly upregulated, while miR-17-5p was downregulated in thyroid cancer tissues and cells, and the miR-17-5p expression in thyroid cancer tissues was inversely correlated with HOTAIR expression. Silencing HOTAIR significantly inhibited the cell viability, migration and invasion of TPC-1 and FTC-133 cells. MiR-17-5p was a target of HOTAIR and counter-regulated by HOTAIR.HOTAIR promotes cell viability, migration and invasion in thyroid cancer cells by sponging miR-17-5p. |
| Pubmed ID | 31607138 |
| Year | 2019 |
| Title | Long Non-Coding RNA HOTAIR Promotes Cell Viability, Migration and Invasion in Thyroid Cancer Cells by Sponging miR-17-5p |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |