Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | NA |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, ChIP |
| Sample | cell lines (U937, Kasumi-1) |
| Expression Pattern | up-regulated |
| Function Description | Here, we reported that the expression of HOTAIR was increased in LSC than in normal hematological stem and progenitor cells (HSPCs).HOTAIR knockdown extends the survival time in U937-transplanted NSG mice. Mechanistically, HOTAIR inhibited p15 expression through zeste homolog 2 (EZH2)-enrolled tri-methylation of Lys 27 of histone H3 (H3K27me3) in p15 promoter. Overexpression of p15 markedly decreased cell growth |
| Pubmed ID | 30172749 |
| Year | 2018 |
| Title | Long noncoding RNA HOTAIR promotes the self-renewal of leukemia stem cells through epigenetic silencing of p15. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for Acute myeloid leukemia | OMIM COSMIC |