Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | NA |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oesophageal cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot |
| Sample | oesophageal cancer cell lines, namely EC8712, EC8733, ECA109, EC9706 and EC8501, normal oesophageal epithelial cell line HEEC, oesophageal cancer tissues, adjacent normal tissues, oesophageal cancer tissues, adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | miR-204 was down-regu- lated, while HOTAIR and HOXC8 were up-regulated in the oesophageal cancer tis- sues. HOTAIR could competitively bind to miR-204 and miR-204 could further target HOXC8. The oesophageal cancer cells treated with si-HOTAIR or miR-204 mimic ex- hibited decreased expression levels of HOXC8, Vimentin and MMP-9, but increased E-cadherin level. Silenced HOTAIR or elevated miR-204 inhibited proliferation, mi- gration and invasion, along with stimulated apoptosis of oesophageal cancer cells. |
| Pubmed ID | 31389660 |
| Year | 2019 |
| Title | Down-regulation of long non-coding RNA HOTAIR inhibits invasion and migration of oesophageal cancer cells via up-regulation of microRNA-204 |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for oesophageal cancer | OMIM COSMIC |