Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | NA |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cutaneous squamous cell carcinoma |
| ICD-0-3 | C49 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | HaCaT (one human keratinocyte cell line) and A431, HSC-5, SCC13, and SCL-1 (four CSCC cell lines), CSCC tissues compared with nonlesional epithelial skin |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR expression in CSCC cell lines exhibited an obvious elevation. Cell function analysis revealed that HOTAIR overexpression remarkably facilitated CSCC cell migration, proliferation and EMT process, which were impeded by down-regulation of HOTAIR. Furthermore, HOTAIR competitively bound to miR-326, so as to positively modulate miR-326 expression. |
| Pubmed ID | 31649487 |
| Year | 2019 |
| Title | Long non-coding RNA HOTAIR functions as a competitive endogenous RNA to regulate PRAF2 expression by sponging miR-326 in cutaneous squamous cell carcinoma |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for cutaneous squamous cell carcinoma | OMIM COSMIC |