Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cardia adenocarcinoma |
| ICD-0-3 | C16.0 |
| Methods | qPCR, RFLP-PCR etc. |
| Sample | blood |
| Expression Pattern | up-regulated |
| Function Description | Among three htSNPs of the HOTAIR gene (rs12826786 C>T, rs4759314 A>G, and rs10783618 C>T), only the T allele of rs12826786 was found to increase the risk of developing GCA and was associated with smoking habit and tumor-node-metastasis (TNM) stage. In addition, higher expression levels of HOTAIR were found in tumor tissues and rs12826786 SNP has a genotype-specific effetc on HOTAIR expression. A high HOTAIR expression level was associated with poor GCA patients' survival. |
| Pubmed ID | 25476857 |
| Year | 2014 |
| Title | Associations between polymorphisms of HOTAIR and risk of gastric cardia adenocarcinoma in a population of north China. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for gastric cardia adenocarcinoma | OMIM COSMIC |