Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | diffuse Large B-Cell Lymphoma |
| ICD-0-3 | NA |
| Methods | qPCR |
| Sample | Lymphoma tissues |
| Expression Pattern | differential expression |
| Function Description | HOTAIR expression could be one of possible mechanisms for inducing H3K27me3 via EZH2-related PRC2 activation, and induced H3K27me3 may be strongly related to aggressive DLBCLs which show poor patient outcome. In Relation to Polycomb Repressive Complex Pathway Proteins and H3K27 Trimethylation |
| Pubmed ID | 27550047 |
| Year | 2016 |
| Title | Long Non-coding RNA HOTAIR Expression in Diffuse Large B-Cell Lymphoma: In Relation to Polycomb Repressive Complex Pathway Proteins and H3K27 Trimethylation |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for diffuse Large B-Cell Lymphoma | OMIM COSMIC |