Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | small cell lung cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, RNAi etc. |
| Sample | cell lines (COLO-668, COR-L51, COR-L88, DMS-79, DMS-53 etc.) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR was expressed highly in pure, rather than combined, SCLC, that the subgroup with high expression had significantly more pure SCLC, more lymphatic invasion and more relapse than the low-expression subgroup. Depletion of HOTAIR resulted in upregulation of cell adhesion-related genes such as ASTN1, PCDHA1, and mucin production-related genes such as MUC5AC, and downregulation of genes involved in neuronal growth and signal transduction including NTM and PTK2B. |
| Pubmed ID | 24591352 |
| Year | 2014 |
| Title | Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for small cell lung cancer | OMIM COSMIC |