Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | cell lines (DU145, PC3) |
| Expression Pattern | down-regulated |
| Function Description | Silenced HOTAIR reduced EZH2 and DNMT1 protein expressions.On the contrary, exogenously expressed HOTAIR resisted PPI-inhibited EZH2 and DNMT1 protein expressions, EZH2 promoter activity and cell growth. Moreover, excessive EZH2 antagonized PPI-suppressed DNMT1 protein expression or vice versa.The interactions among HOTAIR, DNMT1 and EZH2, and reciprocal regulation of DNMT1 and EZH2 contribute to the overall responses of PPI. HOTAIR induced DNA methylation of miR-454-3p via recruiting EZH2 and DNMT1 to the promoter regions of miR-454-3p, this largely reduced miR-454-3p expression,thereby reducing apoptosis and inducing autophagy in human chondrosarcoma cells |
| Pubmed ID | 29221985 |
| Year | 2018 |
| Title | HOTAIR-mediated reciprocal regulation of EZH2 and DNMT1 contribute to polyphyllin I-inhibited growth of castration-resistant prostate cancer cells in vitro and in vivo. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |