Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, in vitro knockdown etc. |
| Sample | cell line (TPC3), FFPE tissue |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR was found to be upreg- ulated in thyroid cancer and promoted proliferation by down- regulating the tumor suppressor miR-1 that inhibits the ex- pression of CCND2 (cyclin D2) |
| Pubmed ID | 29280051 |
| Year | 2017 |
| Title | Long Non-coding RNA Linc-ROR Is Upregulated in Papillary Thyroid Carcinoma. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |