Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Western blot, RIP |
| Sample | renal cell carcinoma tissues, cell lines (769-P and ACHN) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR expression was upregulated, which was correlated with tumor progression, and miR-217 downregulated in Rcc tissues and cells.Importantly,HOTAIR expression was negatively correlated with miR-217 expression in Rcc tissues. |
| Pubmed ID | 28492542 |
| Year | 2017 |
| Title | LncRNA HOTAIR regulates HIF-1a/AXL signaling through inhibition of miR-217 in renal cell carcinoma |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |