Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Luciferase reporter assay etc. |
| Sample | cell lines (HCT116, SW480, LOVO, HT29, FHC) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR knockdown promoted apoptosis and inhibited cell proliferation, migration and invasion in vitro and in vivo.Moreover, HOTAIR modulated the progression of colorectal cancer by competitively binding miR-197.Taken together, our study has identified a novel pathway through which HOTAIR exerts its oncogenic role,and provided a molecular basis for potential applications of HOTAIR in the prognosis and treatment of colorectal cancer. |
| Pubmed ID | 29137688 |
| Year | 2017 |
| Title | The long noncoding RNA HOTAIR promotes colorectal cancer progression by sponging miR-197 |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |