Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot etc. |
| Sample | cell lines (SKOV3, ES-2, OVCAR3, A2780, and COC1) |
| Expression Pattern | down-regulated |
| Function Description | In this study, we report that HOTAIR may function as a ceRNA to regulate the expression of MAPK1 through competition for miR-1, miR-214-3p, or miR-330-5p in ovarian SKOV3 cells, providing a new insight in the treatment of ovarian cancer. |
| Pubmed ID | 26117268 |
| Year | 2015 |
| Title | HOTAIR Interacting with MAPK1 Regulates Ovarian Cancer skov3 Cell Proliferation, Migration, and Invasion |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |