Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | Microarray, qRT-PCR, Western blot, Luciferase reporter assay |
| Sample | glioma tissues, glioma cell lines (U87 and U251) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR was aberrantly up-regulated in glioma tissues and was negatively correlated with miR-126-5p expression.Next, we determined that HOTAIR promote glioma progression by sponging miR-126-5p.Subsequently,glutaminase (GLS) was confirmed to be a direct target of miR-126-5p.Moreover,HOTAIR could modulate GLS expression by functioning as a competing endogenous RNA (ceRNA) for miR-126-5p. |
| Pubmed ID | 29319172 |
| Year | 2018 |
| Title | Long non-coding RNA HOTAIR acts as a competing endogenous RNA to promote glioma progression by sponging miR-126-5p. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |