Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | gastric cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | we found that HOTAIR was more highly expressed in diffuse-type GC than in intestinal type. In the diffuse type, there is significant relationship between HOTAIR expression and DFS. CDH1 was downregulated in diffuse-type GC tissues and showed a negative relationship with HOTAIR. In addition, HOTAIR knockdown significantly repressed migration, invasion and metastasis both in vitro and vivo and reversed the epithelial-to-mesenchymal transition in GC cells. Moreover, it is demonstrated that HOTAIR crosstalk with microRNAs during epigenetic regulation. |
| Pubmed ID | 26136075 |
| Year | 2015 |
| Title | LincHOTAIR epigenetically silences miR34a by binding to PRC2 to promote the epithelial-to-mesenchymal transition in human gastric cancer |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |