Basic Information
| LncRNA/CircRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 |
| Ensemble | ENSG00000228630 |
| Refseq | NR_003716 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Luciferase reporter assay, Western blot, RIP |
| Sample | colorectal cancer tissues, cell lines (CCD18CO, HCT15, CoLo205, HT29, DLD-1, and SW620) |
| Expression Pattern | up-regulated |
| Function Description | The expressions of HOTAIR were upregulated in CRC tissue tissues compared to adjacent control tissues. lncRNA HOTAIR could regulate the progression and chemoresistance of CRC via modulating the expression levels of miR-203a-3p and the activity of Wnt/B-catenin signaling pathway.high expression of HOTAIR was associated with poorer overall survival in CRC patients |
| Pubmed ID | 29680837 |
| Year | 2018 |
| Title | LncRNA HOTAIR is a Prognostic Biomarker for the Proliferation and Chemoresistance of Colorectal Cancer via MiR-203a-3p-Mediated Wnt/Catenin Signaling Pathway. |
External Links
| Links for HOTAIR | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |