Basic Information
| LncRNA/CircRNA Name | HOTAIRM1 |
| Synonyms | NA |
| Region | GRCh38_7:27095647-27100265 |
| Ensemble | ENSG00000233429 |
| Refseq | NR_038366 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR |
| Sample | lung cancer tissues,blood |
| Expression Pattern | down-regulated |
| Function Description | HOTAIRM1 levels were observed to be decreased in the peripheral blood cells of lung cancer patients compared with those of healthy controls. HOTAIRM1/HOXA1 downregulates the immunosuppressive function of MDSCs and may be a potential therapeutic target in lung cancer. |
| Pubmed ID | 32038606 |
| Year | 2018 |
| Title | long non-coding rna hOXa Transcript antisense rna Myeloid-specific 1-hOXa1 axis Downregulates the immunosuppressive activity of Myeloid-Derived suppressor cells in lung cancer |
External Links
| Links for HOTAIRM1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |