Basic Information
| LncRNA/CircRNA Name | HOTAIRM1 |
| Synonyms | NA |
| Region | GRCh38_7:27095647-27100265 |
| Ensemble | ENSG00000233429 |
| Refseq | NR_038366 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase reporter assay etc |
| Sample | PTC tissues and adjacent normal tissues ,cell lines (Nthy-ori 3-1, NPA87, CGTHW-1, K1, B-CPAP, and TPC-1) |
| Expression Pattern | down-regulated |
| Function Description | HOTAIRM1 was significantly downregulated in tumor tissues.The results of qRT-PCR and western blotting assays suggested that HOTAIRM1 could regulate the expression of TDG in an miR-107-meditated manner. In conclusion, we validated HOTAIRM1 as a novel tumor-suppressor lncRNA in PTC and proposed that the HOTAIRM1/miR-107/TDG axis may serve as a therapeutic target for PTC. |
| Pubmed ID | 32269214 |
| Year | 2020 |
| Title | The HOTAIRM1/miR-107/TDG axis regulates papillary thyroid cancer cell proliferation and invasion |
External Links
| Links for HOTAIRM1 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |