Basic Information
| LncRNA/CircRNA Name | HOTAIRM1 |
| Synonyms | HOTAIRM1, HOXA-AS1, HOXA1-AS1, NCRNA00179 |
| Region | GRCh38_7:27095647-27100265 |
| Ensemble | ENSG00000233429 |
| Refseq | NR_038366 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR etc. |
| Sample | lung cancer tissues |
| Expression Pattern | down-regulated |
| Function Description | HOTAIRM1, could delay tumor progression and enhance the antitumor immune response by downregulating the immunosuppression of MDSCs. HOTAIRM1/HOXA1 downregulates the immunosuppressive function of MDSCs and may be a potential therapeutic target in lung cancer. |
| Pubmed ID | 29662483 |
| Year | 2018 |
| Title | Long Non-Coding RNA HOXA Transcript Antisense RNA Myeloid-Specific 1-HOXA1 Axis Downregulates the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in Lung Cancer. |
External Links
| Links for HOTAIRM1 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |