Basic Information
LncRNA/CircRNA Name | HOTAIRM1 |
Synonyms | HOTAIRM1, HOXA-AS1, HOXA1-AS1, NCRNA00179 |
Region | GRCh38_7:27095647-27100265 |
Ensemble | ENSG00000233429 |
Refseq | NR_038366 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | lung adenocarcinoma |
ICD-0-3 | C34 |
Methods | qPCR etc. |
Sample | lung cancer tissues |
Expression Pattern | down-regulated |
Function Description | HOTAIRM1, could delay tumor progression and enhance the antitumor immune response by downregulating the immunosuppression of MDSCs. HOTAIRM1/HOXA1 downregulates the immunosuppressive function of MDSCs and may be a potential therapeutic target in lung cancer. |
Pubmed ID | 29662483 |
Year | 2018 |
Title | Long Non-Coding RNA HOXA Transcript Antisense RNA Myeloid-Specific 1-HOXA1 Axis Downregulates the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in Lung Cancer. |
External Links
Links for HOTAIRM1 | GenBank HGNC NONCODE |
Links for lung adenocarcinoma | OMIM COSMIC |