Basic Information
| LncRNA/CircRNA Name | HOTTIP |
| Synonyms | HOXA transcript at the distal tip |
| Region | GRCh38_7:27198575-27207259 |
| Ensemble | ENSG00000243766 |
| Refseq | NR_037843 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral tongue squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Dual luciferase reporter assay, Western blot assay |
| Sample | OTSCC tumor tissues,OTSCC cell lines (SCC9, CAL27, and SCC25,UM1) |
| Expression Pattern | up-regulated |
| Function Description | HOTTIP was upregulated in OTSCC tissues and cells, and was highly expressed in positive lymph node metastasis and late-stage OTSCC patients. Silencing HOTTIP impeded proliferation, migration, and invasion of OTSCC cells. Moreover, HOTTIP knockdown inhibited proliferation, migration, and invasion of OTSCC cells by targeting miR-124-3p. |
| Pubmed ID | 31910357 |
| Year | 2020 |
| Title | Downregulation of lncRNA HOTTIP Suppresses the Proliferation, Migration, and Invasion of Oral Tongue Squamous Cell Carcinoma by Regulation of HMGA2-Mediated Wnt/?-Catenin Pathway |
External Links
| Links for HOTTIP | GenBank HGNC NONCODE |
| Links for oral tongue squamous cell carcinoma | OMIM COSMIC |