Basic Information
| LncRNA/CircRNA Name | HOTTIP |
| Synonyms | NA |
| Region | GRCh38_7:27198575-27207259 |
| Ensemble | ENSG00000243766 |
| Refseq | NR_037843 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay etc. |
| Sample | AML cell lines (U-937, THP-1) and normal monocyte cell line (SC) |
| Expression Pattern | up-regulated |
| Function Description | HOTTIP was highly expressed in AML-M5 patients than normal controls.HOTTIP expression was significantly up-regulated in AML cell lines U-937 and THP-1. Up-regulation of HOTTIP remarkably promoted the proliferative potential and cell cycle progression of AML cells.HOTTIP accelerated the proliferative ability and cell cycle of AML cells via up-regulating DDA1 expression by sponging microRNA-608. |
| Pubmed ID | 31002141 |
| Year | 2019 |
| Title | LncRNA HOTTIP Promotes Proliferation and Cell Cycle Progression of Acute Myeloid Leukemia Cells |
External Links
| Links for HOTTIP | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |