Basic Information
| LncRNA/CircRNA Name | HOTTIP |
| Synonyms | HOTTIP, HOXA-AS6, HOXA13-AS1, NCRNA00213 |
| Region | GRCh38_7:27198575-27207259 |
| Ensemble | ENSG00000243766 |
| Refseq | NR_037843 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, other |
| Sample | OC tissues and cell lines(OVCAR3, A2780 and SKOV3) |
| Expression Pattern | up-regulated |
| Function Description | Increased lncRNA HOTTIP expression levels were significantly associated with advanced FIGO stage and lymph node metastasis of ovarian cancer patients. Survival plots analysis results showed high lncRNA HOTTIP expression levels in ovarian cancer patients showed a poor prognosis compared to patients with low lncRNA HOTTIP expression levels. Function assays showed that lncRNA HOTTIP knockdown in ovarian cancer cells decreased cell proliferation and cell invasion capacities. Furthermore, we demonstrated that inhibition of lncRNA HOTTIP suppressed Wnt/?-catenin signaling by downregulating ?-catenin expression. |
| Pubmed ID | 30452402 |
| Year | 2019 |
| Title | Long Noncoding RNA HOTTIP Is a Significant Indicator of Ovarian Cancer Prognosis and Enhances Cell Proliferation and Invasion |
External Links
| Links for HOTTIP | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |