Basic Information
| LncRNA/CircRNA Name | HOTTIP |
| Synonyms | HOTTIP, HOXA-AS6, HOXA13-AS1, NCRNA00213 |
| Region | GRCh38_7:27198575-27207259 |
| Ensemble | ENSG00000243766 |
| Refseq | NR_037843 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, RNAi, other |
| Sample | OS tissues and cell lines (SaoS2, HOS, U2OS, MG63) |
| Expression Pattern | up-regulated |
| Function Description | HOTTIP was demonstrated to be upregulated in OS tissues and cell lines; knockdown of HOTTIP inhibited OS cell migration, invasion and EMT, and suppressed c-Myc expression. In addition, overexpression of c-Myc increased HOTTIP expression and enhanced OS cell migration and invasion. HOTTIP promoted cell migration and invasion by upregulating c-Myc in OS. The positive feedback loop formed by HOTTIP and c-Myc may contribute to OS progression, and HOTTIP may act as a therapeutic target for OS. |
| Pubmed ID | 31423232 |
| Year | 2019 |
| Title | lncRNA HOTTIP Facilitates Osteosarcoma Cell Migration, Invasion and Epithelial-Mesenchymal Transition by Forming a Positive Feedback Loop With c-Myc |
External Links
| Links for HOTTIP | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |