Detail

Basic Information

LncRNA/CircRNA Name	HOTTIP
Synonyms	HOTTIP, HOXA-AS6, HOXA13-AS1, NCRNA00213
Region	GRCh38_7:27198575-27207259
Ensemble	ENSG00000243766
Refseq	NR_037843

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	non small cell lung cancer
ICD-0-3	C34
Methods	qPCR, Western blot, Luciferase reporter assay, RIP, other
Sample	NSCLC tissues and cell lines (A549, H1299)
Expression Pattern	up-regulated
Function Description	Hypoxia induced glycolysis, increased HOTTIP and HMGB3 mRNA levels and repressed miR-615-3p expression in NSCLC cells. HOTTIP deficiency or miR-615-3p expression restoration repressed hypoxia-induced glycolysis. Moreover, HOTTIP acted as a molecular sponge for miR-615-3p and HMGB3 was a direct target of miR-615-3p. The inhibitory effect of HOTTIP deficiency on glycolysis under hypoxic exposure was reversed by miR-615-3p restoration. Additionally, HOTTIP regulated HMGB3 expression by acting as a molecular sponge of miR-615-3p in NSCLC cells. In conclusion, our study suggested that HOTTIP might promote glycolysis under hypoxic conditions at least partly through regulating miR-615-3p/HMGB3 axis in NSCLC cells.
Pubmed ID	31422060
Year	2019
Title	Long Non-Coding RNA HOTTIP Promotes Hypoxia-Induced Glycolysis Through Targeting miR-615-3p/HMGB3 Axis in Non-Small Cell Lung Cancer Cells

External Links

Links for HOTTIP	GenBank HGNC NONCODE
Links for non small cell lung cancer	OMIM COSMIC