Basic Information
| LncRNA/CircRNA Name | HOTTIP |
| Synonyms | NA |
| Region | GRCh38_7:27198575-27207259 |
| Ensemble | ENSG00000243766 |
| Refseq | NR_037843 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Luciferase reporter assay, in vitro knockdown, etc. |
| Sample | NPC tissues, NPC cell lines (C666-1 and SUNE-1) and the normal nasopharyngeal cell line NP69 |
| Expression Pattern | up-regulated |
| Function Description | HOTTIP expression was increased in NPC tissues. Higher levels of HOTTIP are correlated with lower survival in NPC patients. HOTTIP silencing suppressed the proliferation, cell cycle, migration, and invasion of NPC cells. HOTTIP served as a sponge for miR-4301. miR-4301 expression was significantly inhibited by HOTTIP in NPC cells. miR-4301 overexpression dramatically inhibited NPC cell proliferation, migration, and invasion. Conclusions: This study showed that HOTTIP acts as an oncogene in NPC by sponging miR-4301. |
| Pubmed ID | 30685769 |
| Year | 2019 |
| Title | Long Noncoding RNA HOTTIP Promotes Nasopharyngeal Cancer Cell Proliferation, Migration, and Invasion by Inhibiting miR-4301. |
External Links
| Links for HOTTIP | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |