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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating	2
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	colorectal cancer
ICD-0-3	C19.9
Methods	qPCR, Western blot
Sample	colorectal cancer tissue or normal tissue, blood
Expression Pattern	down-regulated
Function Description	a highly significant association between low/intermediate expression of exosome-derived HOTTIP and poor overall survival (Low/intermediate: 47.0 months, High: 80.4 months, p=0.0009) (Figure 3C, Table 1), whilst no statistical significance in overall survival was observed depending on H19 and HULC expression (Supplementary Figure 1a and b). In addition, the number of positive lymph nodes (p=0.026) was a significant prognostic marker (Table 1, Supplementary Figure 1c). Multivariate analysis confirmed low expression of HOTTIP as an independent prognostic marker for overall survival (HR: 4.5, CI: 1.69 - 11.98, p=0.0027), whereas the lymph node status failed to be significant (Table 2). Next, we assessed the expression of HOTTIP, H19 and MALAT1 in an independent cohort of patients with CRC27 to confirm our findings. Of note, overall survival data was not available for HULC. In concordance with the exosomal expression, low/intermediate expression of HOTTIP in primary CRC tissue was an indicator for poor survival (Figure 3D) (HR: 0.6, CI: 0.37 - 0.98, p=0.039) in a cohort of 308 patients with CRC. We also found a significantly lower expression of HOTTIP and H19 in these tumor tissues (n=2110) compared to normal tissue (n=40) (p<0.05, respectively, Figure 3E and 3F) whilst no significant difference in the expression of MALAT1 was observed between normal and cancerous tissue (p=0.25) (Figure 3G).
Pubmed ID	31251124
Year	2019
Title	Low levels of exosomal long non-coding RNA HOTTIP is a prognostic biomarker in colorectal cancer

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