Basic Information
| LncRNA/CircRNA Name | HOTTIP |
| Synonyms | HOTTIP, HOXA-AS6, HOXA13-AS1, NCRNA00213 |
| Region | GRCh38_7:27198575-27207259 |
| Ensemble | ENSG00000243766 |
| Refseq | NR_037843 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | small cell lung cancer |
| ICD-0-3 | C56.9 |
| Methods | Microarray, qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RNAi, RIP |
| Sample | FFPE tissues, SCLC cell lines (H69, H69AR, H446, H446AR) |
| Expression Pattern | up-regulated |
| Function Description | HOTTIP functioned as an oncogene in SCLC progression by binding miR-216a and abrogating its tumor-suppressive function in this setting.On the other hand,HOTTIP increased the expression of anti-apoptotic factor BCL-2,another important target gene of miR-216a,and jointly enhanced chemoresistance of SCLC by regulating BCL-2. |
| Pubmed ID | 29367594 |
| Year | 2018 |
| Title | Long non-coding RNA HOTTIP promotes BCL-2 expression and induces chemoresistance in small cell lung cancer by sponging miR-216a. |
External Links
| Links for HOTTIP | GenBank HGNC NONCODE |
| Links for small cell lung cancer | OMIM COSMIC |