Basic Information
| LncRNA/CircRNA Name | HOXA |
| Synonyms | HOTTIP |
| Region | GRCh38_7:27198575-27207259 |
| Ensemble | ENSG00000243766 |
| Refseq | NR_037843 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR etc. |
| Sample | GC tissues, cell lines (MGC-803, BGC-823, SGC-7901 and HGC-27) |
| Expression Pattern | down-regulated |
| Function Description | Li et al reported that HOTTIP was upregulated in pancreatic cancer and may promote cancer cell proliferation, invasion and chemoresistance by regulating HOXA13.Survival rates, including overall survival and disease-free survival were calculated using the Kaplan-Meier method with the log-rank test applied for comparison. A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of HOTTIP expression levels. |
| Pubmed ID | 28693275 |
| Year | 2017 |
| Title | Long non-coding RNA HOXA transcript at the distal tip as a biomarker for gastric cancer. |
External Links
| Links for HOXA | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |