Basic Information
| LncRNA/CircRNA Name | HOXA10-AS |
| Synonyms | NA |
| Region | GRCh38_7:27168619-27171915 |
| Ensemble | ENSG00000253187 |
| Refseq | NR_046609 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qRT-PCR |
| Sample | AML patient samples,AML cell lines EOL-1, MOLM-13, MV4-11, and NB-4, and HEK293T cells |
| Expression Pattern | up-regulated |
| Function Description | Using short hairpin RNA- and locked nucleic acid-conjugated chimeric antisense oligonucleotide (LNA-GapmeR)-mediated HOXA10-AS-knockdown and CRISPR/Cas9-mediated excision in vitro, we demonstrate that HOXA10-AS acts as an oncogene in KMT2A-rearranged AML. Moreover, HOXA10-AS knockdown severely impairs the leukemic growth of KMT2A-rearranged patient-derived xenografts in vivo, while high HOXA10-AS expression can serve as a marker of poor prognosis in AML patients. |
| Pubmed ID | 31867596 |
| Year | 2019 |
| Title | The Stem Cell-Specific Long Noncoding RNA HOXA10-AS in the Pathogenesis of KMT2A-rearranged Leukemia |
External Links
| Links for HOXA10-AS | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |