Basic Information
| LncRNA/CircRNA Name | HOXA10-AS |
| Synonyms | HOXA11-AS, HOXA-AS5, HOXA11-AS1, HOXA11AS, HOXA11S, NCRNA00076 |
| Region | GRCh38_7:27168619-27171915 |
| Ensemble | ENSG00000240990 |
| Refseq | NR_002795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot |
| Sample | glioma tissues, cell lines (A172, U251) |
| Expression Pattern | up-regulated |
| Function Description | HOXA10-AS was significantly upregulated in glioma tissues and cell lines, and increased HOXA10-AS expression levels were associated with higher grades of glioma. Knockdown of HOXA10-AS inhibited glioma cell proliferation and increased cell apoptosis rates compared with the control cells. HOXA10-AS promoted cell growth and survival through activation of HOXA10 gene expression in glioma. |
| Pubmed ID | 30132568 |
| Year | 2018 |
| Title | HOXA10-AS: A novel oncogenic long non-coding RNA in glioma. |
External Links
| Links for HOXA10-AS | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |