Basic Information
| LncRNA/CircRNA Name | HOXA11-AS |
| Synonyms | NA |
| Region | GRCh38_7:27184518-27189293 |
| Ensemble | ENSG00000240990 |
| Refseq | NR_002795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blot, RIP |
| Sample | GC tissues,cell lines |
| Expression Pattern | up-regulated |
| Function Description | HOXA11-AS and WNT1 expression levels were upregulated, while miR-148a level was downregulated in GC tissues and cell lines relative to matched controls.HOXA11-AS increased -catenin pathway activity, which was abolished by miR-148a overexpression in GC cells. |
| Pubmed ID | 32009419 |
| Year | 2020 |
| Title | LncRNA HOXA11-AS Promotes Migration and Invasion Through Modulating miR-148a/WNT1/?-catenin Pathway in Gastric Cancer |
External Links
| Links for HOXA11-AS | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |