Basic Information
| LncRNA/CircRNA Name | HOXA11-AS |
| Synonyms | NA |
| Region | GRCh38_7:27184518-27189293 |
| Ensemble | ENSG00000240990 |
| Refseq | NR_002795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | RT-qPCR, Western blot |
| Sample | HCC tissues,cell lines (SMMC-7721, HCCLM3, HepG2, Hep3B, and Huh7) |
| Expression Pattern | up-regulated |
| Function Description | Both HOXA11-AS silencing and HOXA11 overexpression suppressed the self-renewal, proliferation, migration, and tumorigenicity of HCC stem cells in vivo, as evidenced by the decreased expression of cancer stem cell surface markers (CD133 and CD44) and stemness-related transcription factors (Nanog, Sox2, and Oct4). |
| Pubmed ID | 31757938 |
| Year | 2019 |
| Title | Silencing of long noncoding RNA HOXA11-AS inhibits the Wnt signaling pathway via the upregulation of HOXA11 and thereby inhibits the proliferation, invasion, and self-renewal of hepatocellular carcinoma stem cells |
External Links
| Links for HOXA11-AS | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |