Basic Information
| LncRNA/CircRNA Name | HOXA11-AS |
| Synonyms | homeobox A11 antisense |
| Region | GRCh38_7:27184518-27189293 |
| Ensemble | ENSG00000240990 |
| Refseq | NR_002795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | RT-qPCR, Western blot Assay, Luciferase Reporter Assay |
| Sample | NSCLC tissues,bronchial epithelial cell line 16HBE,NSCLC cell lines (95D, H460, H1299) |
| Expression Pattern | up-regulated |
| Function Description | HOXA11-AS expression was notably upregulated and miR-148a-3p expression was conspicuously downregulated in NSCLC tissues and cells. HOXA11-AS knockdown curbed NSCLC cell proliferation and promoted cell apoptosis through directly increasing miR-148a-3p expression. HOXA11-AS knockdown suppressed NSCLC xenograft growth by upregulating miR-148a-3p and downregulating DNMT1 in vivo. |
| Pubmed ID | 31908486 |
| Year | 2019 |
| Title | Long Non-Coding RNA HOXA11-AS Promotes Non-Small Cell Lung Cancer Tumorigenesis Through microRNA-148a-3p/DNMT1 Regulatory Axis |
External Links
| Links for HOXA11-AS | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |