Basic Information
| LncRNA/CircRNA Name | HOXA11-AS |
| Synonyms | NA |
| Region | GRCh38_7:27184518-27189293 |
| Ensemble | ENSG00000240990 |
| Refseq | NR_002795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | retinoblastoma |
| ICD-0-3 | C69.2 |
| Methods | qRT-PCR , Luciferase reporter assay , in vitro knockdown etc. |
| Sample | RB tissues and normal retina tissues ,human retinal epithelial cells ARPE-19 , human RB cell lines(Y79, Weri-Rb1, SO-Rb50, and HXO-RB44) |
| Expression Pattern | up-regulated |
| Function Description | HOXA11-AS expression was markedly elevated in RB tissues and cell lines compared to normal retina tissues and human retinal epithelial cells, respectively.Knockdown of HOXA11-AS in RB cells significantly suppressed cell proliferation, and induced cell cycle arrest at G1/G0 phase and promoted cell apoptosis.HOXA11-AS could serve as a ceRNA that inhibited miR-506-3p expression, which regulated its downstream target NIMA-related kinase 6 (NEK6) in RB.In addition, miR-506-3p inhibitors partially reversed the effect of HOXA11-AS depletion on proliferation, cycle arrest and apoptosis in RB cells. |
| Pubmed ID | 31123409 |
| Year | 2019 |
| Title | Long Non-Coding RNA Homeobox A11 Antisense RNA (HOXA11-AS) Promotes Retinoblastoma Progression via Sponging miR-506-3p |
External Links
| Links for HOXA11-AS | GenBank HGNC NONCODE |
| Links for retinoblastoma | OMIM COSMIC |